Just when Californians are finally feeling upbeat again about where the state is heading, here comes a fresh downer: The federal sequester cuts set to kick in this week could cost California billions of dollars and hundreds of thousands of jobs while making most of our daily lives more difficult. The state's budget may be balanced and the economy improving, but unless congressional Republicans and President Barack Obama reach a last-minute deal, the federal government on Friday will begin slashing $85 billion this year, including about 8 percent from the Pentagon and about 5 percent from most other discretionary programs.